UK Clinical Trial for Opioid Therapy Moves Closer to Market

LEXINGTON, Ky. (Jan. 23, 2017) — A multi-site clinical trial led by researchers at the University of Kentucky Center on Drug and Alcohol Research (CDAR) has demonstrated the effectiveness of CAM2038, a potentially transformative buprenorphine therapy for moderate-to-severe opioid use disorders.
The randomized, double-blind clinical trial compared the performance of weekly and monthly CAM2038, a fluid crystal depot buprenorphine therapy developed by Braeburn Pharmaceuticals and Camurus, with the current standard of care, a daily sublingual dose of buprenorphine/naloxone. In this Phase III trial, non-inferiority was demonstrated on the primary responder rate outcome, which was based upon highly sensitive urine testing detecting illicit opioids.
The 36-site trial, led by Dr. Michelle Lofwall in UK’s CDAR, established the drug’s non-inferiority to the current daily sublingual treatment, a critical milestone in the application for FDA approval. While results indicated CAM2038 met non-inferiority, a key secondary outcome demonstrated that CAM2038 was superior to current standard treatment based on a pre-defined cumulative distribution function of illicit opioid use. 
Opioid overdose causes more than 30,000 deaths every year, and 2.6 million Americans suffer from an opioid use disorder. More than 12.5 million people misused a prescription opioid pain reliever and 800,000 used heroin in 2015. The National Institutes on Drug Abuse has called for safe, proven solutions to initiate treatment and stabilize patients through an extended opioid maintenance and recovery program. The Surgeon General’s Report has called for more access to evidence-based effective treatments, such as buprenorphine, for opioid use disorders.
The study’s positive results provide a firm foundation of supportive evidence necessary for entering the FDA-approval submission process. Evidence from the trial suggests people with a moderate-to-severe opioid use disorder might benefit from receiving an injectable therapy administered on a weekly or monthly basis. The weekly injection is appropriate for induction and initial stabilization, and the monthly injection is conducive for stabilized patients.  Together, both week and monthly medications allow for flexible and individualized dosing that is critical for optimal patient outcomes and recovery from a deadly disease.
Lofwall, a psychiatrist and associate professor in the UK College of Medicine, served as principal investigator on the study along with Sharon Walsh, director of the CDAR. Lofwall, who sees patients’ personal struggles with opioid use disorder in clinical practice, stresses the need for progressive and practical therapies to treat opioid addiction. An injectable therapy administered in a clinician’s office eliminates the risk of diverting traditional forms of buprenorphine and decreases the risk of relapse and overdose related to non-adherence. The discreet nature of the therapy also eliminates some stigma and shame felt by patients taking oral opioid maintenance medications in daily life.CDAR. Lofwall, who sees patients’ personal struggles with opioid use disorder in clinical practice, stresses the need for progressive and practical therapies to treat opioid addiction. An injectable therapy administered in a clinician’s office eliminates the risk of diverting traditional forms of buprenorphine and decreases the risk of relapse and overdose related to non-adherence. The discreet nature of the therapy also eliminates some stigma and shame felt by patients taking oral opioid maintenance medications in daily life.
“If approved, the CAM2038 weekly and monthly injectable buprenorphine medications can improve how we treat opioid addiction and decrease the stigma associated with the medication that is in large part due to concerns about non-adherence and diversion,” Lofwall said. “Together with the six-month buprenorphine implant, these new long-acting medication delivery systems would allow us to administer a proven medication to the patients directly, ensuring adherence, leading to improved medication efficacy as demonstrated in this trial as well as avoiding the potential for missed or stolen doses, diversion or accidental pediatric exposure, which are significant public health concerns.”
Braeburn Pharmaceuticals, an Apple Tree Partners company, is a commercial-stage pharmaceutical company delivering individualized medicine in neuroscience. Long-acting therapeutic treatment options can be essential to improving patient outcomes and facilitating recovery in neurological and psychiatric disorders, which are often complicated by stigma and present significant public health challenges.
MEDIA CONTACT: Elizabeth Adams,

Does Jazz Music Need Star Power?

Pop has Taylor Swift and Justin Bieber. Country has Carrie Underwood and Luke Bryan. Hip-hop has Kanye West and Beyoncé.
Contemporary music is a star-studded affair that employs sex and spectacle as the best revenue boons. This represents a problem for jazz, which has fallen so far out of sync with popular culture that it has ranked dead last in annual album sales several years running. One of the genre’s elder statesmen and few true present-day stars, Wynton Marsalis, has long recognized this troubling trend and is trying to revitalize what was once known as America’s music. But how?
Harvard Business School professor Rohit Deshpandé has been following and advising Marsalis on his efforts. Their relationship began while Marsalis was featured on a panel at the Harvard Innovation Lab focusing on the “Artist as Entrepreneur.” Marsalis sought out Deshpandé afterward for his marketing and branding expertise, and their conversation eventually led to a 2015 HBS multimedia case titled “Wynton Marsalis & Jazz at Lincoln Center.” The case prompts students to apply marketing principles to the various challenges facing the famed New York City venue as it pursues its mission of entertaining, enriching and expanding a global community for jazz through performance, education, and advocacy. It has since been taught widely to MBA students and Executive Education participants as well as trustees and advisors at Jazz at Lincoln Center itself.

“Though jazz is a uniquely American cultural idiom, the case makes for a fascinating discussion no matter what because there is so much at play with this music,” Deshpandé said in a recent interview. “It has rebellion and history and culture and race. There are so many issues that all come out in a single class.”
In the Executive Education program, where students are older and some grew up in or near jazz’s heyday, the focus is typically on restoring or at least preserving the genre’s vibrant legacy.
For younger MBA students, however, who never experienced jazz as the music of rebellion and experimentation, or the kind of thing you cut loose and danced to, the problem is more clinical. In an age of multiple and constant threats to album sales, how can a genre stay afloat by recruiting new and younger audiences?
“There was one student who said it pretty bluntly: ‘Jazz needs sex appeal’,” Deshpandé said. “They were sure it just couldn’t compete with the Beyoncés and Rihannas of the world otherwise.”
Jazz’s waning popularity is ironic, given that it was once as cool and star-powered and, indeed, as sexy as any form of entertainment is today. Much of modern music stands on the shoulders of towering jazz figures like Ella Fitzgerald, Miles Davis, Billie Holiday, and John Coltrane, whose influence continues even if it is unrecognizable to younger audiences. But call it a sign of the times that just two versions of Beyoncé singing Etta James’s jazz standard “At Last” account for almost 20 million views on Youtube—about four times the total number of jazz albums sold in 2014.

Easy as it is to reduce jazz’s decline to a lack of star power, the reality of the situation is much more complex. Deshpandé points to a wide variety of sophisticated issues that plague most arts and cultural institutions today, Jazz at Lincoln Center among them:
The Greying of the Audience: Many arts institutions’ business models are built around season ticket holders, who represent consistent yearly revenues. That audience segment is aging, however, and the model doesn’t work as well for recruiting younger audiences, who are averse to putting money down in advance and have less disposable income.
Value and Values Creation: Deshpandé sees many cultural organizations as being in the business not just of creating value, but of values creation. “If what we’re talking about here is a cultural product and trying to disseminate it, the essence of that product is a set of values,” he said. “So if it’s jazz, it’s the values around what we might think of as America’s classical music. The cultural value there can sometimes outweigh the monetary value. The challenge becomes: how do you get your audience to appreciate and buy into that?”
Segmentation: Who are your customers and how do you segment already-fractured groups? What is the balance between educating potential consumers and talking down to them? These questions are made more difficult when applied to audiences that are increasingly distracted by so many other devices and genres vying for their attention.
Customer Centricity: Deshpandé coined this phrase, which he says is central to the challenge of capturing new audiences. “It’s not giving the customer what they want,” he said. “The customer wants everything yesterday, for free. It’s understanding the life, world, and heart of your customer so you can make them happier.” In this way, cultural institutions need to think creatively about audience engagement and how they can make the music and the experience more fun for their patrons. This could mean working popular music into the jazz lexicon, or encouraging the use of social media during performances. “We ask jazz audiences to file in, turn off their phones, and be quiet for two hours, when we should be thinking of ways to get people excited and participating before the show,” he said.
High Culture: Like classical music, jazz has a canon that many of its proponents are protective of, even if they cannot agree on who should be in it. The sanctity of the canon can be off-putting, especially for younger audiences, and makes jazz culture inaccessible where other genres openly cater to their audience’s identities and interests. “Jazz artists haven’t historically had to explain why they’ve chosen to play what they’re playing,” Deshpandé said. “But maybe going forward they should. I think especially in America, where the conception of art has not been public art, or free art, the burden of proof is on these institutions and the artists if they want people to support them.”

Given these challenges, saving jazz music is a tall order without an easy answer. The upshot for students, however, is the difficulty of the problem makes for the best kind of classroom experience.
“It’s a continuous learning process,” Deshpandé said of teaching the Lincoln Center case. “Every time I engage with it, I learn something new and it heads in a different direction. That’s the magic of the case process—the classroom becomes an atmosphere and a context of discovery. In that way, I suppose it’s quite a lot like the music we’re discussing.”

Southampton Football Club scores ticketing win with Advanced

Southampton Football Club (FC) has announced its decision to partner with Advanced and implement its innovative ticketing ecommerce solution, TALENT Sport, as part of a multi-year agreement. Improving the overall fan experience when purchasing online, especially during periods of high demand, the solution will help to increase the club’s volume of online ticket sales through a fully mobile responsive site and intuitive online customer journey.
Southampton FC will use fan data held within the solution to engage with fans online, targeting them with relevant promotions based on their preferences and interests, as well as providing an easier ticket buying process. All online purchases will be managed through the TALENT Sport website, ensuring a fast and secure online experience that allows customers to make multiple purchases in one single transaction, on a range of devices.
“It was an easy decision to choose Advanced’s solution,” commented Danielle Lewis, Head of Ticketing & Hospitality at Southampton FC. “It was essential that we used technology to lead the way in our fan engagement strategy, and Advanced’s track record and credentials in the sports sector are second to none. We have been working collaboratively with Advanced to define our requirements and objectives and we are confident that they will enable us to achieve our goals, improve our fans’ online experience and deliver a first-class solution.”
The highly robust software, which operates 24/7 in the private cloud, guarantees first rate levels of service and performance. Southampton FC will also benefit from Advanced’s buy-back system, which allows season ticket holders (STH) who cannot make a match to release their ticket back to the club. The club will also be able to manage the secure sale of the ticket to another fan, as well as driving value for the STH.
Mark Dewell, MD, Specialist Solutions – Advanced, concludes: “Fans are leading the way in the digital era, expecting around the clock, fast and reliable access from any device when purchasing from clubs. It’s rewarding to see a number of clubs recognising that our solution can deliver that connected fan experience. We are looking forward to helping Southampton FC keep one-step ahead of their fans’ requirements now and for the long term.”
Note to editors:
*Advanced Computer Software Group was renamed Advanced on April 11 2016, as part of a global rebrand.
About Advanced
Through our enterprise and market focused solutions we positively impact millions of people’s lives through continually investing in our people, partnerships and own technologies to stay focused on our markets’, customers’ and their stakeholders’ needs. We enable our customers to drive efficiencies, savings and growth opportunities through focused, right-first-time software solutions that evolve with the changing needs of their business and the markets they operate in. True partnership is the defining thing that makes us different from the competition. We pride ourselves on delivering focused software solutions for public sector, enterprise commercial and health & care organisations that simplify complex business challenges and deliver immediate value.
Advanced is a Sunday Times Top Track 250 Company 2016 and was ranked in the Deloitte UK Fast 50 which recognises the 50 fastest growing technology companies in the UK and a winner of the Tech Company of the Year in PwC’s UK Tech Awards in 2014.
For further media information, please contact
Andrea Hounsham, Firework PR – email: or call: 07783 535928
Clare Wall, Firework PR – email: or call: 07974 161127

The Forbes 30 Under 30 Honorees of 2017 to Ring The Nasdaq Stock Market Closing Bell January 24, 2017

What:The honorees of Forbes’ sixth annual, 2017, 30 Under 30 list and past list members, along with Forbes magazine Editor Randall Lane, will ring the Nasdaq Stock Market Closing Bell at the Nasdaq MarketSite in Times Square on January 24, 2017.
Participating members of Forbes’ 30 Under 30 list include: Sean Petterson, Strong Arm Technologies; Emily Motayed, Havenly; Alaa  Murabit, UN High-Level Commissioner on Health Employment & Economic Growth; Quardean Lewis-Allen, Made in Brownsville; Kerri Cohen, Goldman Sachs; James Heller, Wrapify; Evin Floyd Robinson and Jessica Santana, New York on Tech; Andy Stafman, Sachem Head Capital Management; Michael Martin, RapidSOS; Chef Chloe Coscarelli, by CHLOE; Chef Daniela Sotto Ines, Cosme; Carrie Hammer, fashion designer; and Karim Abouelnaga, CEO at Practice Makes Perfect.
From an initial screening list of more than 15,000 candidates, the Forbes 30 Under 30 class of 2017 represents 600 bright young entrepreneurs, breakout talent and change agents in 20 different categories.
Where:Nasdaq MarketSite – 4 Times Square – 43 [rd] & Broadway – Broadcast Studio
When:Tuesday, January 24, 2017 – 3:45 p.m. to 4:00 p.m. ET  
Forbes Media Contact:Laura Daunis (212) 367-4874
Nasdaq MarketSite:Emily Pan (646) 441-5120
Feed Information:Fiber Line (Encompass Waterfront): 4463
Gal 3C/06C 95.05 degrees West 18 mhz Lower DL 3811 Vertical FEC 3/4 SR 13.235 DR 18.295411 MOD 4:2:0 DVBS QPSK
Social Media:For multimedia features such as exclusive content, photo postings, status updates and video of bell ceremonies, please visit our Facebook page:
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Webcast: A live stream of the Nasdaq Closing Bell will be available at: or
Photos: To obtain a hi-resolution photograph of the Market Close, please go to and click on the market close of your choice.
About Forbes 30 Under 30Forbes’ Under 30 franchise is a global multichannel platform, which comprises 30 Under 30 lists published in print and online all over the world; live summits in the U.S., Asia and Israel; an Under 30 channel on; and a Forbes Under 30 app. To learn more about the 2017 Forbes 30 Under 30 list, visit:
About NasdaqNasdaq

NDAQ, -0.97%

is a leading provider of trading, clearing, exchange technology, listing, information and public company services across six continents. Through its diverse portfolio of solutions, Nasdaq enables customers to plan, optimize and execute their business vision with confidence, using proven technologies that provide transparency and insight for navigating today’s global capital markets. As the creator of the world’s first electronic stock market, its technology powers more than 70 marketplaces in 50 countries, and 1 in 10 of the world’s securities transactions. Nasdaq is home to more than 3,700 listed companies with a market value of $10.0 trillion and approximately 18,000 corporate clients. To learn more, visit: or  
Copyright (C) 2017 GlobeNewswire, Inc. All rights reserved. an important source for snowmobile safety

EAST LANSING, MI–(Marketwired – January 23, 2017) – Finding information about snowmobiling safety courses across the country is as easy as going online. The website — a collaboration between the American Council of Snowmobile Associations (ACSA), the International Snowmobiler Manufacturers Association (ISMA), and the U.S. Federal Highway Administration (FHWA) — is a comprehensive website supplying detailed information on safety education resources, avalanche education and information, training manuals, access resources and other pertinent snowmobiling information for snowmobilers, the general public, snowmobiling management agencies and land managers.

The NBA and GE Healthcare Issue a Call for Proposals to Address Prevention, Diagnosis and Treatment of Bone Stress Injuries and Announce Latest Round of Research Awards

CHICAGO & NEW YORK–(BUSINESS WIRE)–Today, the National Basketball Association (NBA) & GE Healthcare (NYSE:
GE) Orthopedics and Sports Medicine Collaboration issued a new call for
proposals (CFP) focused on bone stress injuries (BSI), a frequent and
debilitating injury for both the elite and the everyday athlete. The
collaboration simultaneously announced the latest round of winning
research proposals that address myotendinous injuries, specifically
targeting strains, tears, ruptures, or pulls of the hamstring and calf.

The NBA & GE Healthcare Orthopedics and Sports Medicine Collaboration
was established to fund research that addresses the prevention,
diagnosis and treatment of musculoskeletal injuries* affecting NBA
players and everyday athletes. Through the funded research, the
collaboration aims to increase understanding of the mechanisms of injury
to reduce the impact of future injuries by investigating prevention and
rehabilitation programs and developing new and improved tools for
diagnosis and treatment. The collaboration is directed by a Strategic
Advisory Board, led by Dr. John DiFiori, the NBA’s Director of Sports
Medicine, and an NBA & GE Healthcare Steering Committee.

The latest call for research proposals is aimed at advancing the
understanding of prevention, diagnosis, treatment, and recovery of bone
stress injuries (BSI) in elite and everyday athletes. BSI can impair
performance, limit playing time, disrupt an athletic career, and cause
ongoing risk of re-injury.

“GE Healthcare is excited to collaborate with the NBA and invest in
this research,” said John Sabol, Chief Scientist for Global Research
at GE Healthcare. “Together, we hope to encourage the scientific and
clinical research communities worldwide to bring their skills and ideas
to advance, as well as challenge, established paradigms in an effort to
better understand and improve the prevention, diagnosis, treatment, and
recovery of bone stress injuries.”

Specific areas of research interest for this
CFP include:

Advancements in imaging to improve prevention, diagnosis, and/or
treatment of BSI – including imaging techniques to improve the
understanding of bone health and risk factors for BSI and re-injury.

Prevention and management of BSI – including quantifiable
exposure factors, metabolic factors, bone quality thresholds and
biomechanical risk factors, and epidemiological determinants.

Additionally, as part of their collaboration, the NBA and GE Healthcare
today announced the awardees of four research proposals selected from
investigators across the globe to address acute myotendinous injuries.

“Myotendinous injuries are a common issue among basketball players at
all levels of the game – from NBA players to the athlete joining a local
pick-up game,” said Dr. DiFiori. “While there are prevention
programs prescribed for varying levels of play, we are working to
increase our understanding of the best techniques for clinical
assessment and choices of imaging modalities to improve health outcomes
and limit the impact on athletic performance for athletes at all levels.”

Using a competitive application process with a rigorous scientific
review, leading academic and healthcare institutions were selected from
the following locations:

University of Newcastle, Australia (Dr. Suzi Edwards) The HAMI Study:
Investigating Hamstring and Adductor Myotendinous Injury Risk Factors in
Basketball.Dr. Edwards and her team will study top male
Australian basketball players to determine the role of biomechanical
(how a person moves) and neural (how the brain signals muscles) factors
in muscle injuries. This novel multidisciplinary research may lead to
improved injury prevention and rehabilitation programs for athletes by
increasing our understanding of how an athlete runs, how muscle
structure changes, and how an injury alters brain signals to muscles.

Academic Medical Center, Amsterdam (Dr. Johannes Tol) Game changing
innovative sports research: The Basketball and Muscle Injury (BAMI)
study.The BAMI study targets preventing hamstring and calf
muscle injuries and re-injuries. In the first of three separate studies,
researchers in Amsterdam will use magnetic resonance imaging (MRI) to
examine what actually goes on within injured muscles to help in
preventing re-injury. The second and third studies will use strength
testing and MRI to determine which exercises are the best for preventing
hamstring and calf muscle injuries.

University of Wisconsin-Madison (Dr. Bryan Heiderscheit) Clinical,
Biomechanical, and Novel Imaging Biomarkers of Hamstring Strain Injury
Potential in Elite Athletes.Investigators from The University
of Wisconsin will conduct a prospective longitudinal study of high-level
athletes to improve risk assessment for hamstring strain injuries.
Athletes will be monitored for exposure and injury throughout training
and competition with injured athletes monitored with diffusion tensor
magnetic resonance and shear wave ultrasound imaging during and after
their rehabilitation period. Findings from this study may improve injury
risk assessment and establish objective criteria to assess the risk of
re-injury upon returning to play.

The Mayo Clinic (Dr. Timothy Hewett) Comparative Effectiveness of
Hamstring Muscle Strain Injury Prevention Programs.Dr. Hewett
and his team at the Mayo clinic will investigate the effectiveness of
hamstring muscle strain injury prevention programs in 1000 high school
basketball athletes. They plan to study how these programs impact
flexibility, muscle stiffness, strength and power. They will use an
advanced ultrasound imaging technique (shear wave elastography) to
measure muscle stiffness and determine if it can be used to predict
future hamstring injuries.

Beginning today, research proposals are being accepted here.
This CFP will award a total of up to $1.5 million over a three-year
period to support research addressing important unanswered questions
regarding BSI prevention, diagnosis, and treatment. The maximum amount
for an individual submission is $300,000 including direct and indirect
costs for the entire research period. Smaller, focused, and impactful
projects requiring less support are strongly encouraged.

The deadline to submit BSI research proposals is April 17, 2017. For
more information about these calls for proposals and/or the application
process, please visit the website at

*Musculoskeletal disorders (MSDs) are injuries or disorders of the
muscles, nerves, tendons, joints, cartilage, and disorders of the
nerves, tendons, muscles and supporting structures of the upper and
lower limbs, neck, and lower back that are caused, precipitated or
exacerbated by sudden exertion or prolonged exposure to physical factors
such as repetition, force, vibration, or awkward posture. Source:

About GE Healthcare

GE Healthcare provides transformational medical technologies and
services to meet the demand for increased access, enhanced quality and
more affordable healthcare around the world. GE (NYSE: GE) works on
things that matter – great people and technologies taking on tough
challenges. From medical imaging, software & IT, patient monitoring and
diagnostics to drug discovery, biopharmaceutical manufacturing
technologies and performance improvement solutions, GE Healthcare helps
medical professionals deliver great healthcare to their patients. For
more information visit our website

About the NBA

The NBA is a global sports and media business built around three
professional sports leagues: the National Basketball Association, the
Women’s National Basketball Association, and the NBA Development League.
The league has established a major international presence with games and
programming in 215 countries and territories in 49 languages, and NBA
merchandise for sale in more than 125,000 stores in 100 countries on 6
continents. NBA rosters at the start of the 2016-17 season featured a
record 113 international players from 41 countries and territories. NBA
Digital’s assets include NBA TV,
and the NBA App, which achieved record viewership and traffic during the
2015-16 season. The NBA has created one of the largest social media
communities in the world, with more than 1.3 billion likes and followers
globally across all league, team, and player platforms. Through NBA
Cares, the league addresses important social issues by working with
internationally recognized youth-serving organizations that support
education, youth and family development, and health-related causes.

J.J. Yeley Joins Superior Essex at BICSI Winter 2017

ATLANTA–(BUSINESS WIRE)–Superior Essex is excited to announce that J.J. Yeley and the TriStar
Motorsports team will be joining the company at the 2017 BICSI Winter
Conference and Exhibition booth #845 for its showcase of the Speed
eXPerience. As a part of its Speed eXPerience, Superior Essex
is working with NASCAR and its sponsors to generate new relationships
and create a new demand for its products throughout the NASCAR industry.
Currently, Superior Essex is sponsoring the No. 14 Toyota for thirteen
races during the 2017 season, with Yeley behind the wheel.

J.J. Yeley began his racing career at age 14, rising to prominence as he
continued to add victories and record-breaking performances to his track
record. In 1998 at the age of 21, he became the youngest driver at the
time to qualify for the Indianapolis 500. In 2003, he broke the record
for single-season victories with 24 USAC wins, and joined Tony Stewart
as only the second driver in USAC history to win the “Triple Crown” by
taking the Midget, Sprint and Silver Crown championships in a single
season. In addition to racing, Yeley participates in numerous charities
nationwide, with a special interest in children’s charities and fund
raising events.

“We are thrilled to have J.J. at our booth this year to support the
Speed eXPerience,” says Ken Braziel, Vice President of Enterprise Sales
at Superior Essex. “He’s one of the best drivers on the track today, and
he brings a lot of great energy and excitement along with him. This is
great opportunity to share some of that excitement with the ICT
community, and to highlight the positive relationships we are forming
between our two industries as well.”

The 2017 BICSI Winter Conference and Exhibition will be held at the
Tampa Convention Center in Tampa, Florida, January 22-26, 2017. For more
information about BICSI Winter, visit the website.

About Superior Essex

Superior Essex is a leading manufacturer and supplier of communications
cable and accessory products serving the communications industry and
related distribution markets for over 80 years. Superior Essex is a
trade name for Superior Essex International LP and other companies of
Superior Essex Inc.